Sean Penn

Stephen balks at a scientific study saying that chimpanzees are more evolved than humans in DNA. On "The Word," he talks about John Edwards' $400 haircut and considers him going over to the Republican party. Colbert then interviews Sean Penn, and leads to a Meta-Free-Phor-All hosted by Pinsky (the decider of topics for the rounds used humorous pictures and sound effects in the style of The Daily Show's "God Machine," which Colbert usually took part in).